Statins do not prevent acute organ failure in ventilated ICU patients: single-centre retrospective cohort study.

Introduction: Observational studies suggest statin therapy reduces incident sepsis, but few studies have examined the impact on new organ failure. We tested the hypothesis that statin therapy, administered for standard clinical indications to ventilated intensive care unit patients, prevents acute organ failure without harming the liver.

Methods: We performed a retrospective, single-centre cohort study in a tertiary mixed medical/surgical intensive care unit.