Secondary metabolites of the leaves of N. Hallé (Rubiaceae) and their potential antiplasmodial activity.

One monoterpene indole alkaloid, atheruramine () bearing an ether bridge linking, one hydrobenzoin derivative, tricalydioloside () and two ursane-type triterpenes, atherurosides (A and B) ( and ) were isolated from the leaves of , together with eight known compounds. The structures of these new compounds were elucidated on the basis of the results of spectroscopic analysis, and the relative configurations of compounds were established by NOE difference. Four of the metabolites were screened against both chloroquine (CQ)-sensitive (3D7) and -resistant (Dd2) strains of ; they were found to exhibit moderate activity against chloroquine-resistant (Dd2) (IC 64.

Antibacterial and cytotoxic activities of undescribed cassiaric acid and other constituents from stem barks.

A new lupane-type triterpene, 2,3-dihydroxylupan-29-oic acid (), and one new ceramide derivative: (2,2',3,4,57',11,12',20)--[2'-hydroxyoctadeca-6,11-dienoyl]-2-aminohexacosa-11,20-diene-1,3,4,5-tetrol () were isolated from the ethyl acetate fraction obtained from the methanol extract of the stem barks of together with seven known compounds. Their structures were characterized using two-dimensional NMR, mass spectrometry, and compared with reported data. To date, this is the first report of the isolation of a multiple double bonds sphingolipid type from this genus.

New flavonoids C-glycosides from Rhabdophyllum arnoldianum.

Two new flavone glycosides, 3″-O-acetyl-7-O-methylvitexin (1) and 6″-α-rhamnopyranosyl-7-O-methylvitexin (2), along with nine known compounds (3-11) were isolated from the leaves of Rhabdophyllum arnoldianum (Ochnaceae). The structures of the new compounds were established by detailed spectroscopic studies and mass spectrometry, while known compounds were characterised by direct comparison of their reported NMR data with those found in the literature. All these compounds were the first reported from Rhabdophyllum genus.