Rational pharmacological approaches for cognitive dysfunction and depression in Parkinson's disease.

Parkinson's disease (PD) is not a single entity but rather a heterogeneous neurodegenerative disorder. The present study aims to conduct a critical systematic review of the literature to describe the main pharmacological strategies to treat cognitive dysfunction and major depressive disorder in PD patients. We performed a search of articles cited in PubMed from 2004 to 2014 using the following MeSH terms (Medical subject headings) "Parkinson disease"; "Delirium," "Dementia," "Amnestic," "Cognitive disorders," and "Parkinson disease"; "depression," "major depressive disorder," "drug therapy.

[Validation of the Epworth sleepiness scale in Mexican population].

Introduction: The Epworth sleepiness scale (ESS) is a widely used instrument in the subjective assessment of sleepiness. Although there are several translations into Spanish, their equivalence to the original version is questionable.

Objective: To assess the reliability and validity of a true translation into Spanish of the ESS in Mexican population.