Publications by authors named "Maritza A Jimenez"
Article Synopsis
- In sickle cell disease, the abnormal polymerization of hemoglobin S leads to hemolysis and blockage of small blood vessels, contributing to complications like acute chest syndrome.
- Researchers used advanced imaging techniques on SCD mice and blood samples to investigate the role of the immune system in causing lung vasoocclusion and injury.
- They found that platelet activation linked to an inflammasome response results in the formation of inflammatory molecules and platelet-neutrophil aggregates that hinder blood flow, suggesting new therapeutic targets could help prevent acute chest syndrome.
CCP-224 attenuates neutrophil-platelet aggregation in SCD patient blood. CCP-224 has the potential to prevent vaso-occlusion in SCD patients.
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- This study investigates how sickle cell disease (SCD) causes blockages in lung blood vessels, leading to lung injuries during crises.
- Researchers used advanced imaging in mice with SCD and found that neutrophils and platelets form clumps that block tiny lung arteries and worsen the condition.
- Targeting specific molecules on platelets may offer a new treatment approach to prevent lung complications in SCD patients by reducing these harmful aggregates.