Familial migraine with aura: association study with 5-HT1B/1D, 5-HT2C, and hSERT polymorphisms.

Background: The serotonergic system has a significant role in the pathophysiology and pharmacology of migraine.

Objective: To study the association between the occurrence of migraine with aura and 5-HT(1B/1D) and 5-HT(2C) receptor gene and the human serotonin transporter (hSERT) gene polymorphisms in 18 unrelated families with multiple affected members.

Method: Two polymorphisms in the 5-HT(1B/1D) receptor gene and one polymorphism in the 5-HT(2C) receptor gene were studied by restriction fragment length polymorphism analysis.