Nitrous oxide for applying local anesthesia in nasal operations: a randomized placebo-controlled single-blinded study.

Conclusions: In our study setting nitrous oxide (N(2)O) did not show any clinical benefit in discomfort experienced when applying local anesthesia for nasal operations. Further studies with longer inhalation times are needed to elucidate the role of N(2)O in application of local anesthesia in nasal surgery.

Objectives: N(2)O inhalation reduces the discomfort experienced in various medical procedures.