Influence of the Vehicle and Antibiotic Formulation on Cytotoxicity of Triple Antibiotic Paste.

Introduction: The aim of this study was to assess the influence of antibiotic formulations (tablet/capsule [TC] or United States Pharmacopeia [USP]-grade antibiotics) and vehicles (water [HO] or macrogol + propylene glycol [MP]) on the cytotoxicity and pH of triple antibiotic pastes (TAPs).

Methods: L929 fibroblasts were exposed to TAPs prepared with TC or USP-grade antibiotics mixed with HO or MP for 72 hours. Each isolated antibiotic with each vehicle, each isolated vehicle, and the culture medium were used as controls.

Cellular and molecular tissue response to triple antibiotic intracanal dressing.

Introduction: The aim of this study was to characterize the response of mouse subcutaneous tissue to triple antibiotic paste (TAP) using conventional light microscopy and real-time PCR (qRT-PCR).

Methods: Polyethylene tubes containing TAP or calcium hydroxide (CH) (ie, the control group) were implanted in mouse subcutaneous tissue. Animals that received empty tubes or no tubes were used as additional controls.

Children's toothbrush contamination in day-care centers: how to solve this problem?

Objective: To evaluate the contamination level of toothbrushes by mutans streptococci (MS) and the efficacy of antimicrobial solutions: cetylpyridinium chloride 0.05 % (CPC; Cepacol™) and chlorhexidine 0.12 % (CHX; Periogard™), to disinfect toothbrushes of preschool-aged children in day-care centers.

Response of mice connective tissue to intracanal dressings containing chlorhexidine.

Substances containing chlorhexidine (CHX) have been studied as intracanal medicaments. The aim of the present study was to characterize the response of mouse subcutaneous connective tissue to CHX-containing medications by conventional optical microscopy. The tissue response was evaluated by implanting polyethylene tubes containing one of the substances evaluated: Calen paste + 0.