Revascularization of the ischemic hand with arterialization of the venous system.

Chronic ischemia in the upper extremity is a challenging condition for both patients and surgeons. When ischemia reaches a critical level, tissue loss ensues, which results in necrosis of fingers at various levels. Amputation of necrotic digits, without addressing the etiology of the necrosis, often results in wound-healing problems and more proximal amputations.

Adoptive transfer of islet antigen-autoreactive T cell clones to transgenic NOD.Ea(d)mice induces diabetes indicating a lack of I-E mediated protection against activated effector T cells.

Transgenic insertion of the MHC class II Ea(d)gene in NOD mice restores I-E expression and prevents T-cell-mediated autoimmune diabetes (IDDM). The specific molecular and cellular mechanisms responsible for the diabetes resistance of transgenic NOD.Ea(d)mice remain unclear.