Publications by authors named "Marissa Mueller"
Article Synopsis
- Bidirectional communication between neurons and glial cells is essential for proper brain function, but the effects of sudden changes in neuronal activity on these interactions are not well understood.
- In this study, researchers used a technique called DREADD to manipulate specific neuron populations in mouse brains, discovering that activating neurons leads to reduced synaptic density and increased glial cell reactivity, while silencing them has the opposite effect.
- The findings highlight rapid and dynamic interactions between neurons and glial cells that are influenced by neuronal activity, contributing to our understanding of brain function and potential implications for neurological conditions.
Article Synopsis
- Current treatments for dysphagia in ALS fail to address the root causes like tongue weakness and muscle atrophy, prompting a study using the LCN-SOD1 mouse model to explore this issue.
- The study followed 125 LCN-SOD1 offspring to analyze limb strength's impact on dysphagia and survival rates; results showed a high occurrence of swallowing difficulties in mixed phenotype mice compared to hindlimb phenotype mice.
- Findings indicated that both mouse groups had significant tongue muscle atrophy, supporting the potential of this model for developing targeted treatments for dysphagia in ALS.
Unlabelled: Objective measurement of physical activity (PA) using accelerometers has become increasingly popular across recreational and clinical applications. However, the effects of multiple processing algorithms, filters, and corrections on PA measurement variability may be underappreciated.
Objective: To examine how lifestyle PA estimates are impacted by multiple available scoring methods.