Publications by authors named "Marissa McDonald"
Article Synopsis
- The bacterium that causes tuberculosis, a significant global health issue, is responsible for over a million deaths annually, highlighting the need for shorter and simpler treatment options.
- Research shows that this bacterium can adapt its metabolism during nutrient starvation, which occurs during infection, allowing it to withstand standard antibiotic treatments.
- A genetic study identified 220 mutant strains of the bacterium with different responses to key antibiotics, revealing several genes that may serve as potential therapeutic targets to improve treatment effectiveness.
Dynabeads are superparamagnetic particles used for immunomagnetic purification of cells and biomolecules. Post-capture, however, target identification relies on tedious culturing, fluorescence staining and/or target amplification. Raman spectroscopy presents a rapid detection alternative, but current implementations target cells themselves with weak Raman signals.
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- * The study focused on understanding how the bacterium adapts to nutrient starvation during infection, which helps it survive against antibiotics like rifampin and isoniazid, by conducting a genetic screen to identify related genes.
- * Researchers discovered 220 mutants with different antibiotic responses under nutrient-rich conditions and 82 mutants under nutrient-starved conditions, revealing promising genetic targets that may contribute to more effective and shorter TB treatments.
Allogeneic hematopoietic cell transplantation (HCT) patients are at an increased risk of developing central line-associated bloodstream infections (CLABSIs) due to prolonged periods of myelosuppression, immunosuppression, and indwelling catheter days. CLABSIs are among the most serious complications in HCT recipients and can lead to prolonged hospitalizations, intensive care unit admissions, lengthy antimicrobial therapies, and increased mortality. There is a lack of data regarding the incidence and risk factors associated with the development of CLABSIs in the HCT population undergoing outpatient transplantation.
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