Publications by authors named "Marissa L Streitz"
Article Synopsis
- The study aimed to assess how disease-modifying treatments (DMT) for Alzheimer’s disease (AD) affect the duration of independence in daily living activities among individuals with very mild to mild AD dementia.
- It followed 282 participants over about 2.9 years, finding that loss of independence in instrumental activities (IADLs) typically occurred when CDR-SB scores reached above 4.5, and for basic activities (BADLs) above 11.5.
- Notably, treatments like lecanemab and donanemab were associated with extended periods of independence in IADLs, with lecanemab offering an average of 10 months and donanemab providing an average of 13
Introduction: Research addressing Alzheimer disease and related dementias must examine nonbiological factors influencing the risk for and expression of Alzheimer disease and related dementias. These factors address the interplay of cognition with lived experiences and social and structural determinants of health (SSDOH). However, coordinated measures of SSDOH are limited.
View Article and Find Full Text PDFStructural and social determinants of health (SSDoH) are environmental conditions in which individuals are born, live, learn, work, play, worship, and age that affect health, functioning, and quality-of-life outcomes across the life course. Growing evidence suggests that SSDoH can help to explain heterogeneity in outcomes in Alzheimer's disease and Alzheimer's disease and related dementias (AD/ADRD) research and clinical practice. The National Institute on Aging has prioritized collecting SSDoH data to elucidate disease mechanisms and aid discovery of disease-modifying treatments.
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