Publications by authors named "Marissa L Buchan"
Article Synopsis
- Intestinal microbiota plays a crucial role in various diseases, and understanding diet's impact on it is essential for developing targeted therapies.
- A study analyzing meals and stool samples from 173 hospitalized patients found that higher caloric intake is linked to greater fecal microbiota diversity.
- The research indicates that consuming sweets or sugars while on antibiotics may disrupt the microbiome, suggesting that reducing sugar intake during such treatment could help protect gut health.
Purpose: Nutritional status is an established driver of cancer outcomes, but there is an insufficient workforce of registered dietitians to meet patient needs for nutritional counseling. Artificial intelligence (AI) and machine learning (ML) afford the opportunity to expand access to guideline-based nutritional support.
Methods: An AI-based nutrition assistant called Ina was developed on the basis of a learning data set of >100,000 expert-curated interventions, peer-reviewed literature, and clinical guidelines, and provides a conversational text message-based patient interface to guide dietary habits and answer questions.
Background: Dysgeusia is a common but understudied complication in patients undergoing autologous hematopoietic cell transplantation (auto-HCT). We assessed the feasibility of using chemical gustometry (CG) to measure dysgeusia and explored its associations with symptom burden, nutrition, chemotherapy pharmacokinetics (PK), and the oral microbiome.
Methods: We conducted a single-center, prospective feasibility study (NCT03276481) of patients with multiple myeloma undergoing auto-HCT.
Unlocking the Complex Flavors of Dysgeusia after Hematopoietic Cell Transplantation.
Biol Blood Marrow Transplant
March 2018
Dysgeusia is a frequently occurring symptom after hematopoietic cell transplantation (HCT) that has important long-term effects on physical, nutritional, and immunologic recovery, as well as on quality of life. Despite the relevance of this symptom, the study of dysgeusia in patients undergoing HCT has been limited, owing in part to its complexity. In this article, we review normal taste function and its clinical evaluation, discuss how dysgeusia uniquely affects patients undergoing HCT, and examine distinct, transplantation-related contributors to dysgeusia that may help elucidate strategies to ultimately reduce this symptom burden after transplantation.
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