Publications by authors named "Marissa K Oram"
Article Synopsis
- - Tobacco use is linked to various cancers and causes about 25% of cancer-related deaths, primarily due to harmful substances in tobacco smoke, including tobacco-specific nitrosamines like NNN and NNK that create damaging DNA adducts.
- - The study identified new mutational patterns induced by these DNA adducts, particularly in certain cancer cell lines and rat tumors, indicating specific mutations that occur in the DNA from exposure to these harmful compounds.
- - Analyzing 2,780 cancer genomes revealed that these mutational patterns were present in around 180 tumors from types of cancer not typically associated with smoking, suggesting that the damage caused by the POB pathway could play a unique role in various cancers, including hematological
Article Synopsis
- Eukaryotic genome stability relies on various molecular processes, including the action of STUbLs (SUMO-targeted E3 ligases) that support DNA repair and replication.
- This study investigates the role of the human STUbL RNF4 in cancer cells lacking MCM10, highlighting its importance in preventing G-phase accumulation and promoting DNA synthesis under replication stress.
- Findings indicate that RNF4 and MCM10 function differently in humans compared to yeast, with RNF4 helping to avoid severe DNA under-replication when MCM10 is deficient, ultimately ensuring cell viability.
Article Synopsis
- Small ubiquitin-like modifier (SUMO)-targeted E3 ubiquitin ligases (STUbLs) are enzymes that add ubiquitin to proteins that have been modified by SUMO, linking the processes of SUMOylation and ubiquitination in cells.
- STUbLs play essential roles in various cell cycle events, such as DNA repair, replication, and mitosis, and can respond to stress from DNA damage.
- They often function in specific locations within the cell, like the nuclear envelope, to help correctly reposition damaged DNA or stalled replication processes, thereby supporting genome stability.
Minichromosome maintenance protein 10 (MCM10) is essential for eukaryotic DNA replication. Here, we describe compound heterozygous MCM10 variants in patients with distinctive, but overlapping, clinical phenotypes: natural killer (NK) cell deficiency (NKD) and restrictive cardiomyopathy (RCM) with hypoplasia of the spleen and thymus. To understand the mechanism of MCM10-associated disease, we modeled these variants in human cell lines.
View Article and Find Full Text PDFTobacco smoke is a complex mixture of chemicals, many of which are toxic and carcinogenic. Hazard assessments of tobacco smoke exposure have predominantly focused on either single chemical exposures or the more complex mixtures of tobacco smoke or its fractions. There are fewer studies exploring interactions between specific tobacco smoke chemicals.
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