Obstructive Sleep Disorders in Down Syndrome's Children with and without Lower Airway Anomalies.

(1) Background: Obstructive sleep apnea (OSA) and lower airway anomalies are both highly prevalent in children with Down syndrome (DS). However, little is known on the interaction between both. We aim to investigate the co-occurrence of OSA (defined as obstructive apnea/hypopnea index (oAHI) ≥ 2/h) and lower airway anomalies in children with DS and explore their impact on OSA severity and treatment outcome.

Lower airway microbiota in children with Down syndrome compared to controls with similar respiratory symptomatology.

Background: Children with Down syndrome (DS) often present with chronic or recurrent respiratory symptoms and generally have a more severe and prolonged disease course in case of infection. This can be caused by anatomical and/or immunological predisposition. With this study, we aim to compare microbial composition in the lower airways of patients with DS versus controls, to see if we can explain the difference in disease course.

Pulmonary complications in children with Down syndrome: A scoping review.

Context: Down syndrome (DS) is a prevalent chromosomal disorder associated with a wide range of congenital anomalies and other health problems.

Objectives: To give a scoping overview of encountered lower airway problems (both infectious and non-infectious) in DS children.

Data Sources: We systematically searched the MEDLINE and PubMed databases for relevant publications.

The prevalence of lower airway anomalies in children with Down syndrome compared to controls.

Introduction: Children with Down syndrome (DS) often present with chronic respiratory symptoms. Congenital airway anomalies have been described but data about prevalence is scarce and a comparison to controls is lacking. We aim to compare the endoscopic and clinical data of children with DS to controls without significant medical history.