Electrochemical and CD-spectroelectrochemical studies of the interaction between BSA and the complex [Cu(Bztpen)], (Bztpen = (N-benzyl-N, N', N'-tris (pyridin-2-ylmethyl) ethylenediamine).

In this work we report the electrochemical, spectroscopical and spectro-electrochemical studies of a model complex [Cu(Bztpen)], (Bztpen = (N-benzyl-N,N',N'-tris(pyridin-2-ylmethyl)ethylenediamine) in order to propose a methodology to evaluate the interaction of potential metal based anticancer agents during electron transfer processes, with transport proteins such as Bovine Serum Albumin (BSA). It was possible to establish a reversible electron transfer [Cu(Bztpen)] +1e → [Cu(Bztpen)] and a weak interaction energy between BSA and [Cu(Bztpen)] and [Cu(Bztpen)] species, with no adsorption of protein over the electrode surface. Circular Dichroism (CD) Spectroelectrochemistry, not reported before, reveals no significant changes in BSA structure during the electron transfer [Cu(Bztpen)] + 1e → [Cu(Bztpen)].

Self-Assembled Monolayer of Monomercaptoundecahydro--dodecaborate on a Polycrystalline Gold Surface.

In this work, we present an electrochemical study of the boron cage monomercaptoundecahydro--dodecaborate [BHSH] in solution and in a self-assembled monolayer over a polycrystalline gold electrode. Cyclic voltammetry of the anion [BHSH] in solution showed a shift in the peak potentials related to the redox processes of gold hydroxides, which evidences the interaction between the boron cage and the gold surface. For an Au electrode modified with the anion [BHSH], cyclic voltammetry response of the probe Fe(CN)/Fe(CN) showed a ΔEp value typical for a surface modification.

Effect of tunable redox behavior of bis chelate substituted 1,10-phenantroline Cu(II) complexes on its reaction with superoxide anion in DMSO. Toward a simple criterion to identify a SOD-like mechanism.

In this work we report a series of Cu(II) complexes [Cu(N-N)(X)], (N-N=substituted 1,10-phenanthroline derivatives and X=Cl or NO), with tunable E for electrochemical reduction [Cu(N-N)(X)]+1e⇌[Cu(N-N)]+X. The disproportion of O was explored in presence of the electro-generated species [Cu(N-N)] using cyclic voltammetry in a non-aqueous media, arising a new simple method to propose a SOD-like mechanism, which can be used as a quick guide test for a compound, before being proven in biological assays. It was found that complexes with high negative half wave potential values (E) for Cu(II)/Cu(I) couple shown a current increment for oxygen reduction, related to the capability of the disproportion of this reactive oxygen species.