Prediction of bone mass changes after successful parathyroidectomy using biochemical markers of bone metabolism in primary hyperparathyroidism: is it clinically useful?

Objective: To measure type 1 serum amino-terminal propeptide procollagen (P1NP) and type 1 cross-linked C-terminal telopeptide collagen (CTX) before parathyroidectomy (PTX) in PHPT patients, correlating these measurements with bone mineral density (BMD) changes.

Subjects And Methods: 31 primary hyperparathyroidism (HPTP) were followed from diagnosis up to 12-18 months after surgery. Serum levels of calcium, parathyroid hormone (PTH) vitamin D, CTX, P1NP, and BMD were measured before and 1 year after surgery.

Multicenter, randomized, double-blind clinical trial to evaluate efficacy and safety of combined glucosamine sulfate and chondroitin sulfate capsules for treating knee osteoarthritis.

Objectives: To compare the efficacy and safety of a new fixed dose combination of glucosamine sulfate and chondroitin sulfate capsules (GS/CS) versus the fixed dose combination of glucosamine hydrochloride and chondroitin sulfate (Cosamin DS®) in capsules in patients with osteoarthritis (OA) of the knee.

Methods: Multicenter, randomized, double-blind study. Participants with knee OA Kellgren-Lawrence grades 1 to 3 and VAS of symptoms ≥4 cm were randomized to receive GS/CS or Cosamin DS® over 12 weeks.

The benefits of a high-intensity aquatic exercise program (HydrOS) for bone metabolism and bone mass of postmenopausal women.

This study aimed to evaluate the 24-week effects of a high-intensity aquatic exercise program on bone remodeling markers and bone mass of postmenopausal women. In this randomized, controlled trial we studied 108 women (58.8 ± 6.

A specific bioelectrical impedance equation to predict body composition in Turner's syndrome.

Introduction: Cardiovascular disease is one of the main causes for Turner syndrome (TS) mortality and the evaluation of its risk factors such as excess body fat and its distribution is considered one of the major aspects of the adult patient care.

Objective: To develop and validate a specific bioelectrical impedance analysis (BIA) equation to predict body composition in TS patients.

Subjects And Methods: Clinical and anthropometric data, dual-energy X-ray absorptiometry (DXA) for total fat-free mass (FFM) and BIA for resistance and reactance were obtained from 50 adult TS patients.

[Association among weight loss, bone mass, body composition and dietary intake of post-pubertal obese adolescents].

Objective: To verify the effects of weight loss on bone mass of obese adolescents submitted to a nutritional intervention based on a hypocaloric diet and nutritional advice over a nine-month-period.

Methods: Anthropometry, body composition, BMD and dietary intake were evaluated.

Results: Fifty-five adolescents, 78.

[Role of vitamin D in the neuro-muscular function].

Through its action in the kidney, intestines, bone and parathyroid glands vitamin D is a major regulator of calcium homeostasis and for the development of a healthy skeleton. Moreover, receptors for this hormone are present in almost all body tissues and other actions which are not related to the mineral metabolism have been imputed to it. In the skeletal muscle cell, vitamin D acts through the classic mechanism of binding to a nuclear receptor and also by binding to a membrane receptor, carrying out actions that involve calcium transport, protein synthesis and kinetics of muscle contraction.

Aerobic exercise capacity in normal adolescents and those with type 1 diabetes mellitus.

Objective: To compare the aerobic exercise capacity between normal adolescents and those with type 1 diabetes mellitus (T1DM).

Methods: An experimental group with 72 individuals diagnosed with T1DM aged 9--20, time from diagnosis 4.9 +/- 3.

Assessment of body composition by dual energy X-ray absorptiometry, skinfold thickness and creatinine kinetics in chronic kidney disease patients.

Background: Finding a method that can be routinely used to assess body composition with minimum error is still a challenge for those who work with chronic kidney disease (CKD) patients. This study aimed to compare the value of two surrogate techniques, skinfold thickness (SKF) and creatinine kinetics (CK) with dual energy X-ray absorptiometry (DEXA) as the reference method for measuring body fat and fat-free mass in non-dialysed CKD patients.

Methods: The body fat and fat-free mass of 50 non-dialysed CKD patients (38 male, 12 female) were measured by DEXA and compared with measurements obtained by SKF and CK.