Increase of 10% in the Rate of Adverse Drug Reactions for Each Drug Administered in Hospitalized Patients.

Objective: To assess the risk factors, incidence and severity of adverse drug reactions in in-patients.

Methods: This prospective study evaluated 472 patients treated at a teaching hospital in Brazil between 2010 and 2013 by five medical specialties: Internal Medicine, General Surgery, Geriatrics, Neurology, and Clinical Immunology and Allergy. The following variables were assessed: patient age, gender, comorbidities, family history of hypersensitivity, personal and family history of atopy, number of prescribed drugs before and during hospitalization, hospital diagnoses, days of hospitalization.

Nonsteroidal anti-inflammatory drugs are major causes of drug-induced anaphylaxis.

Background: Drugs are responsible for 40% to 60% of anaphylactic reactions treated in the emergency department. A global research agenda to address uncertainties in anaphylaxis includes studies that identify factors associated with morbidity and mortality.

Objective: The present study investigated drug-induced anaphylaxis, etiologies, aggravating factors, and treatment.

Esophageal candidiasis--an adverse effect of inhaled corticosteroids therapy.

Over the last few decades, inhaled corticosteroids (ICs) became the cornerstone in the treatment of persistent asthma. Their use improved asthma control, decreased mortality and also minimized adverse reactions associated with systemic steroid. Esophageal candidiasis is a rare complication resulting from the use of ICs.