Publications by authors named "Marisa J Stachowski"
Patients with diabetes are at significantly higher risk of developing heart failure. Increases in advanced glycation end products are a proposed pathophysiological link, but their impact and mechanism remain incompletely understood. Methylglyoxal (MG) is a glycolysis byproduct, elevated in diabetes, and modifies arginine and lysine residues.
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- Cardiac dyssynchrony in heart failure (HF) leads to increased morbidity and mortality due to conduction problems, and cardiac resynchronization therapy (CRT) aims to improve heart function but its underlying mechanisms are not well understood.
- Researchers examined how HF affects the phospho-proteome (the phosphorylation of proteins) and how CRT influences this by analyzing samples from dog models with control, HF, and CRT conditions, revealing 209 regulated phospho-sites.
- The study found that HF leads to hyper-phosphorylation, particularly in tyrosine phosphorylation, with CK2 signaling being significantly involved, suggesting potential therapeutic targets that could enhance the effectiveness of CRT in future treatments.
The role of heat shock proteins and co-chaperones in heart failure.
Philos Trans R Soc Lond B Biol Sci
January 2018
The ongoing contractile and metabolic demands of the heart require a tight control over protein quality control, including the maintenance of protein folding, turnover and synthesis. In heart disease, increases in mechanical and oxidative stresses, post-translational modifications (e.g.
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