Publications by authors named "Marisa Felice"
An Extensive Quality Control and Quality Assurance (QC/QA) Program Significantly Improves Inter-Laboratory Concordance Rates of Flow-Cytometric Minimal Residual Disease Assessment in Acute Lymphoblastic Leukemia: An I-BFM-FLOW-Network Report.
Margarita Maurer-Granofszky Angela Schumich Barbara Buldini Giuseppe Gaipa Janos Kappelmayer Marisa Felice
Cancers (Basel)
December 2021
Article Synopsis
- - Monitoring minimal residual disease (MRD) through flow cytometry (FCM) is essential for predicting outcomes in acute lymphoblastic leukemia (ALL), but requires skilled laboratory personnel and ongoing quality checks.
- - The international Berlin-Frankfurt-Münster (I-BFM) consortium created a comprehensive training and quality control program to standardize FCM-MRD practices across multiple reference labs.
- - Key elements of this program include a twinning maturation program, mandatory external quality assessments, regular data trials, and independent survey evaluations, resulting in significantly improved accuracy and consistency in MRD detection in pediatric ALL patients.
The aim of this study was to evaluate the influence of the most common genetic variants in methylenetetrahydrofolate reductase (MTHFR), thiopurine methyltransferase (TPMT) and glutathione-S-transferases (GSTs) on the outcome of acute lymphoblastic leukemia (ALL) treatment in Argentinean children. Two hundred and eighty-six patients with ALL treated with two Berlin-Frankfurt-Münster (BFM)-based protocols were analyzed. Ten genetic variants were studied.
View Article and Find Full Text PDF