Publications by authors named "Mariona Riudavets Melia"
Immune-related adverse events (irAEs) are unpredictable autoimmune-like toxicities induced by immune checkpoint inhibitors (ICI). irAEs are a consequence of a breakdown in self-tolerance. ICIs can induce autoantibody formation, and the presence of antinuclear autoantibodies (ANAs) has been reported in patients who developed irAEs.
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- - The study investigates the role of tumor PD-L1 expression as a biomarker in predicting the effectiveness of PD-(L)1 blockade treatments for advanced non-small cell lung cancer (NSCLC) patients, noting that responses can occur regardless of tumor PD-L1 levels.
- - Researchers analyzed blood samples from 119 NSCLC patients, checking for various PD-L1 expressions on immune cells, platelets, and in plasma, alongside tumor PD-L1 levels, to better correlate these factors with treatment efficacy.
- - Findings indicate that incorporating both circulating and tumor PD-L1 data can significantly predict patient outcomes and may guide treatment decisions for those eligible for PD-(L)1 blockade therapy.