Publications by authors named "Marion de Carvalho"
The prevalence of food allergies has increased in recent decades in industrialized developed countries. Defects are influenced by environmental factors in early life, including early colonizers of the human gut microbiota. Therapeutic solutions are limited, and the lack of efficient treatments has led to the search for new treatments, including biotherapies.
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- Asthma affects over 300 million people globally, with 70% of cases linked to allergies, and is characterized by various endotypes and phenotypic diversities influenced by allergen exposure and the airway microbiome.
- The study compared different methods of sensitizing mice to house dust mites (HDM) via oral, nasal, and cutaneous routes, assessing lung function, immune response, and microbial composition.
- Results showed that nasal and cutaneous sensitization led to severe respiratory issues and inflammation, while oral sensitization resulted in milder symptoms, highlighting how the route of sensitization significantly affects asthma's severity and characteristics.
An in vitro approach is proposed to study the release of an Active Pharmaceutical Ingredient-Ionic Liquid (API-IL) from a natural biopolymer matrix based on zein, a maize storage protein. Zein can be processed in the molten state with 20 w% [Lidocainium][Ibuprofenate] added as API-IL also acting as plasticizer and potentially co-plasticized by glycerol. The thermal stability of the matrix is checked, as well as the in vivo biological activity of the API-IL confirming anesthetic and anti-inflammatory activities.
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- - Allergic diseases are on the rise globally, possibly linked to increasing environmental chemical pollution like Bisphenol A (BPA), which affects the immune system and gut health.
- - A study using a mouse model tested the impact of BPA at a level similar to human exposure, revealing that it worsened food allergy symptoms and altered immune responses and gut microbiota.
- - The findings indicate that BPA exposure increases markers of food allergy and intestinal permeability, suggesting the European Food Safety Authority's tolerable daily intake for BPA may need to be reevaluated for its immunotoxic effects.
Background: Regulatory T cells (Tregs) are known to protect against allergies. Moreover, the decrease in the frequency and efficiency of Tregs amplifies allergic symptoms.
Aim: This study investigated whether expanding Tregs in vivo with an IL-2/IL-2 antibody complex could be safe, well tolerated and efficient in a therapeutic setting in allergies.