Publications by authors named "Marion Tschaikin"

Background: Intranasal oxymetazoline (OMZ) is used as a decongestant during common colds. Recently, intracellular adhesion molecule (ICAM) 1 receptor expression in vitro has been shown to be diminished by OMZ. ICAM-1 is the major receptor used by rhinovirus to gain entry to human cells.

View Article and Find Full Text PDF

Oxymetazoline and xylometazoline are both used as nasal mucosa decongesting α-adrenoceptor agonists during a common cold. However, it is largely unknown which of the six α-adrenoceptor subtypes are actually present in human nasal mucosa, which are activated by the two alpha-adrenoceptor agonists and to what extent. Therefore, mRNA expression in human nasal mucosa of the six α-adrenoceptor subtypes was studied.

View Article and Find Full Text PDF
Article Synopsis
  • Oxymetazoline (OMZ) is an effective treatment for rhinitis symptoms caused by Rhinovirus infections, as seen in its use in nose drops and sprays.
  • Research shows that OMZ specifically inhibits Human Rhinovirus (HRV) while having no effect on other viruses like Parainfluenza and Adenovirus.
  • Aside from its ability to constrict blood vessels, OMZ also exhibits strong antiviral and anti-inflammatory properties, making it a potential causal treatment for rhinitis rather than just symptom relief.
View Article and Find Full Text PDF