Publications by authors named "Marion Stange"
Background: The efficacy of acetylcholinesterase inhibitors (AChE-I) might depend on blood concentration. While rivastigmine metabolism is independent of the cytochrome P450 system, its isoenzymes, especially CYP2D6, metabolize donepezil. polymorphisms can cause altered enzyme activity resulting in lower or higher than expected drug concentrations of donepezil.
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- Acetylcholinesterase inhibitors (AChE-I), like donepezil and rivastigmine, are used to help people with dementia, including Alzheimer's, with their thoughts and behavior.
- The study measured the blood levels of these medications in 67 patients to see how effective they were based on those levels.
- Most patients had lower than expected medicine levels, and certain factors like genes and how long they were treated affected these levels for donepezil.