Adverse childhood experiences such as maltreatment or neglect are associated with mental health problems in adulthood. Changes in the regulation of the psychological and physiological stress reaction, mediated via epigenetic modifications, are discussed as potential mechanisms. This study aimed to replicate the role of DNA methylation of the KITLG gene in mediating the association between childhood adversity and stress-induced cortisol reactivity in a sample of adults reporting childhood adversity and a matched control group (N = 60).
View Article and Find Full Text PDFPsychoneuroendocrinology
January 2019
Adverse childhood experience such as neglect or abuse can lead to long-term deficits in emotion processing abilities. Animal studies indicate that oxytocin production and/or sensitivity are influenced by variation in early nurturing experiences. The goal of this study was to test whether emotion recognition abilities and empathy might be improved via intranasal oxytocin administration in adults with a history of childhood maltreatment.
View Article and Find Full Text PDFExposure to serious or traumatic events early in life can lead to persistent alterations in physiological stress response systems, including enhanced cross talk between the neuroendocrine and immune system. These programming effects may be mechanistically involved in mediating the effects of adverse childhood experience on disease risk in adulthood. We investigated hormonal and genome-wide mRNA expression responses in monocytes to acute stress exposure, in a sample of healthy adults (n=30) with a history of early childhood adversity, and a control group (n=30) without trauma experience.
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