Incarnatapeptins A and B, Nonribosomal Peptides Discovered Using Genome Mining and H/N HSQC-TOCSY.

Methods for the focused isolation of low-abundance natural products with specific chemical substructures could expand known bioactive chemical diversity for drug discovery. Here we report the combined use of genome mining and an N NMR-based screening method for the targeted isolation of the low-abundance piperazic-acid-containing peptides incarnatapeptins A () and B (). Incarnatapeptin B () shows cytotoxicity to LNCaP prostate cancer cells.