Alopecia in Harlequin mutant mice is associated with reduced AIF protein levels and expression of retroviral elements.

We investigated the contribution of apoptosis-inducing factor (AIF), a key regulator of mitochondrial biogenesis, in supporting hair growth. We report that pelage abnormalities developed during hair follicle (HF) morphogenesis in Harlequin (Hq) mutant mice. Fragility of the hair cortex was associated with decreased expression of genes encoding structural hair proteins, though key transcriptional regulators of HF development were expressed at normal levels.

Alopecia in a viable phospholipase C delta 1 and phospholipase C delta 3 double mutant.

Background: Inositol 1,4,5trisphosphate (IP(3)) and diacylglycerol (DAG) are important intracellular signalling molecules in various tissues. They are generated by the phospholipase C family of enzymes, of which phospholipase C delta (PLCD) forms one class. Studies with functional inactivation of Plcd isozyme encoding genes in mice have revealed that loss of both Plcd1 and Plcd3 causes early embryonic death.

Specific expression of annexin A8 in adult murine stratified epithelia.

Annexin A8 is a member of the annexin family of calcium-regulated membrane-binding proteins. In this report, we investigated the expression of annexin A8 in adult mouse organs. Northern blot analysis of adult mouse organs showed that a single annexin A8 transcript of 1.

Fxyd3 and Lgi4 expression in the adult mouse: a case of endogenous antisense expression.

We have investigated the expression of Fxyd3 and Lgi4 in the adult mouse by Northern blot analyses and in situ hybridization. Murine Fxyd3 and Lgi4 have been mapped to the same locus on mouse Chromosome (Chr) 7, where the last exon of Fxyd3 completely overlaps with the 3'UTR in the last exon of Lgi4, which is transcribed in the opposite orientation. The Fxyd3 gene (formerly called Mat-8) encodes an 8-kDa transmembrane protein that is upregulated in mammary tumors and can induce a chloride conductance upon RNA injection into Xenopus oocytes.

Murine calmodulin binding protein 1 (Calmbp1): tissue-specific expression during development and in adult tissues.

Expression of the 1.9 kb cDNA of murine Calmbp1 has been shown to interfere with the mitotic S-M checkpoint in yeast (J. Cell Sci.