Publications by authors named "Marion Kunz"
Article Synopsis
- The study analyzed the proteomic profiles of 79 bladder cancer samples, categorizing them into non-muscle-invasive (NMIBC), muscle-invasive (MIBC), and neoadjuvant-treated MIBC groups.
- MIBC showed significant changes in the extracellular matrix and immune response-related proteins, as well as a decrease in proteins related to cell adhesion and lipid metabolism compared to NMIBC.
- The research identified multiple proteomic subgroups within MIBC and NMIBC that correlate with tissue type and metabolic pathways, revealing complex tumor-stroma interactions and significant genomic alterations in the cancers.
Viral vectors used for gene and oncolytic therapy belong to the most promising biological products for future therapeutics. Clinical success of recombinant adeno-associated virus (rAAV) based therapies raises considerable demand for viral vectors, which cannot be met by current manufacturing strategies. Addressing existing bottlenecks, we improved a plasmid system termed rep/cap split packaging and designed a minimal plasmid encoding adenoviral helper function.
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