Publications by authors named "Marion K Raich"
Article Synopsis
- Lumens play a vital role in the architecture of both healthy pancreas tissues and precancerous pancreatic ductal adenocarcinoma (PDAC) lesions, facilitating enzyme transport and cyst-like structures.
- Pancreatic-cancer organoids replicate critical features of both healthy and diseased pancreas, but the transition to hollowness in these structures is not well understood.
- The study identifies two key mechanisms for lumen formation in these organoids: one involves fluid intake leading to multiple microlumen merging, and the other is through the death of central cells, creating hollow spaces.
Organ development involves complex shape transformations driven by active mechanical stresses that sculpt the growing tissue . Epithelial gland morphogenesis is a prominent example where cylindrical branches transform into spherical alveoli during growth. Here we show that this shape transformation is induced by a local change from anisotropic to isotropic tension within the epithelial cell layer of developing human mammary gland organoids.
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