Publications by authors named "Marion J Wood"
Importance: The prevalence, pathophysiology, and long-term outcomes of COVID-19 (post-acute sequelae of SARS-CoV-2 [PASC] or "Long COVID") in children and young adults remain unknown. Studies must address the urgent need to define PASC, its mechanisms, and potential treatment targets in children and young adults.
Observations: We describe the protocol for the Pediatric Observational Cohort Study of the NIH's REsearching COVID to Enhance Recovery (RECOVER) Initiative.
Article Synopsis
- The RECOVER-Pathology study focuses on analyzing the long-term effects of SARS-CoV-2 (long COVID) by examining postmortem tissue to better understand the prevalence and types of organ injuries related to PASC.
- The study will involve detailed autopsies of individuals who died at least 15 days after their initial COVID-19 infection, with the aim of linking pathological findings to clinical characteristics and identifying potential causes of ongoing symptoms.
- As the largest autopsy study on long COVID in the U.S., RECOVER-Pathology seeks to contribute significantly to knowledge about the mechanisms behind organ damage and to help guide future treatments.
Article Synopsis
- - The RECOVER-Pediatrics study aims to investigate the prevalence and long-term effects of Long COVID (PASC) in children and young adults, addressing the need for more research in this area.
- - The study recruits caregiver-child pairs and young adults across 100+ sites in the U.S., focusing on a diverse group of participants with and without prior SARS-CoV-2 infections, and will collect data over several years through various tiers of assessments.
- - The ultimate goal of the study is to understand the clinical trajectory, mechanisms, and sociodemographic factors related to pediatric PASC, thereby contributing to potential treatments and public health responses.