Publications by authors named "Marion G J de Kleijnen"
Purpose: In this study, we explored the role of apoptosis as a potential biomarker for cardiac failure using functional micro-CT and fluorescence molecular tomography (FMT) imaging techniques in Ercc1 mutant mice. Ercc1 is involved in multiple DNA repair pathways, and its mutations contribute to accelerated aging phenotypes in both humans and mice, due to the accumulation of DNA lesions that impair vital DNA functions. We previously found that systemic mutations and cardiomyocyte-restricted deletion of Ercc1 in mice results in left ventricular (LV) dysfunction at older age.
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- Heart failure is becoming more common in older populations, and research suggests that DNA damage plays a key role in this condition.
- Scientists hypothesized that the ability to repair DNA in heart cells is crucial for maintaining heart function, and disrupting certain DNA repair genes (XPG and ERCC1) leads to severe heart problems and early death in mice.
- Analysis revealed that the lack of DNA repair causes increased oxidative stress, fibrosis, and apoptosis in heart tissue, pointing to DNA damage as a potential target for new treatments for heart failure.