Treatment inferred disease severity in Crohn's disease: evidence for a European gradient of disease course.

Objective: Geographic differences in disease course of Crohn's disease (CD) might possibly be related to differences in genetic and environmental factors encountered in different parts of the world. The aim of this study was to assess differences in treatment regimens within a European cohort of CD patients as a reflection of disease course, and to identify associated phenotypic risk factors at diagnosis.

Material And Methods: A prospective European population-based inception cohort of 380 CD patients was studied.