Publications by authors named "Marion Basch"
The mitochondrial translocase Bcs1 is required for the correct assembly of complex III of the mitochondrial respiratory chain. Because of its importance, Bcs1 was recently proposed as a target for antifungal agents. The function of this AAA (ATPase Associated with diverse cellular Activities) protein has been extensively characterized in .
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- The mitochondrial AAA ATPase Msp1 is crucial for extracting mislocalized proteins from the mitochondrial outer membrane and interacts genetically with the proteasome and TOM complex.
- Msp1 and the proteasome work together to eliminate precursor proteins that get stuck during import, with proteasome activity being vital for this process.
- The study also highlights the potential link between Msp1's function and neurodegenerative diseases in humans, showing that its absence can trigger stress responses in other organisms, suggesting a conserved biological role.