Association of Lack of Fear of Dying With New Organ Failure: Results of a Multicenter Prospective Cohort Study.

Background: Patients' anxiety on intensive care unit (ICU) admission is associated with subsequent deterioration.

Objective: To assess whether patients' fears/anxiety are predictive of new organ failure within 7 days of ICU admission.

Methods: In a prospective 3-center cohort study of non-comatose patients without delirium or invasive mechanical ventilation, 9 specific fears were evaluated through yes/no questions.

Association Between Anxiety and New Organ Failure, Independently of Critical Illness Severity and Respiratory Status: A Prospective Multicentric Cohort Study.

Objectives: Anxiety results from the anticipation of a threat and might be associated with poor outcome in the critically ill. This study aims at showing that anxiety at admission in critically ill patients is associated with new organ failure over the first 7 days of ICU hospitalization independently of baseline organ failure at admission.

Design: Prospective multicenter cohort study.

Choosing appropriate size of I-Gel for initial success insertion: a prospective comparative study.

Purpose: The optimal size of the I-Gel remains unclear since the manufacturer's weight-based formula (size 3 for weight < 50 kg, size 4 for weight 50-90 kg, and size 5 for weight > 90 kg) for the laryngeal mask airway I-Gel is not evidence-based. We hypothesised that sex may also guide the choice of I-Gel size.

Methods: Insertion success rates of the I-Gel chosen according to the weight-based formula were prospectively recorded and compared with those of a patients' cohort ventilated with an I-Gel chosen according to the sex-based formula recorded.

Predictors of pre-procedural concentrations of direct oral anticoagulants: a prospective multicentre study.

Aims: Patients receiving direct oral anticoagulants (DOACs) frequently undergo elective invasive procedures. Their management is challenging. We aimed to determine the optimal duration of DOAC discontinuation that ensures a minimal anticoagulant effect during the procedure.

Brainstem response patterns in deeply-sedated critically-ill patients predict 28-day mortality.

Background And Purpose: Deep sedation is associated with acute brain dysfunction and increased mortality. We had previously shown that early-assessed brainstem reflexes may predict outcome in deeply sedated patients. The primary objective was to determine whether patterns of brainstem reflexes might predict mortality in deeply sedated patients.

Pheochromocytoma Crisis in the ICU: A French Multicenter Cohort Study With Emphasis on Rescue Extracorporeal Membrane Oxygenation.

Objectives: To describe the characteristics, management, and outcome of patients admitted to ICUs for pheochromocytoma crisis.

Design: A 16-year multicenter retrospective study.

Setting: Fifteen university and nonuniversity ICUs in France.

Acute kidney injury after out-of-hospital cardiac arrest: risk factors and prognosis in a large cohort.

Purpose: Characteristics of acute kidney injury (AKI) occurring after out-of-hospital cardiac arrest (OHCA) are incompletely described. We aimed to evaluate the prevalence of AKI, identifying risk factors and assessing the impact of AKI on outcome after OHCA.

Methods: Single-center study between 2007 and 2012 in a cardiac arrest center in Paris, France.

Jugular versus femoral short-term catheterization and risk of infection in intensive care unit patients. Causal analysis of two randomized trials.

Rationale: When subclavian access is not possible, controversy exists between the internal jugular and femoral sites for the choice of central-venous access in intensive care unit patients.

Objectives: To compare infection and colonization rates of short-term jugular and femoral catheters.

Methods: Using data from two multicenter studies, we compared femoral and internal jugular for the risks of catheter-related bloodstream infection, major catheter-related infection, and catheter-tip colonization.

Decompression sickness in urban divers in France.

Background: Decompression sickness (DCS) can occur in SCUBA divers. DCS is treated with oxygen, preferably given under hyperbaric conditions. Although Paris (France) is located at a distance from the sea or lakes, some injured divers require hyperbaric oxygen treatment (HBOT) in this city, sometimes within a specific time frame.

Randomized controlled trial of chlorhexidine dressing and highly adhesive dressing for preventing catheter-related infections in critically ill adults.

Rationale: Most vascular catheter-related infections (CRIs) occur extraluminally in patients in the intensive care unit (ICU). Chlorhexidine-impregnated and strongly adherent dressings may decrease catheter colonization and CRI rates.

Objectives: To determine if chlorhexidine-impregnated and strongly adherent dressings decrease catheter colonization and CRI rates.

Combined loss of cRel/p50 subunits of NF-κB leads to impaired innate host response in sepsis.

NF-κB, which comprises homo- and hetero-dimers of the five members of the Rel family, plays a crucial role in immunity to infection. The cRel and p50 subunits have been implicated in the development and function of the immune cells, but their in vivo importance remains poorly explored in sepsis. We aimed to study the impact of the combined loss of these two subunits on the innate response to infection in a cecal ligation and puncture model of sepsis.

Designing and conducting a randomized trial for pandemic critical illness: the 2009 H1N1 influenza pandemic.

Purpose: To analyze the hurdles in implementing a randomized trial of corticosteroids for severe 2009 H1N1 influenza infections.

Methods: This was an investigator-led, multicenter, randomized, placebo-controlled, double-blind trial of corticosteroids in ICU patients with 2009 H1N1 influenza pneumonia requiring mechanical ventilation. The feasibility of and hurdles in designing and initiating a phase III trial in a short-lived pandemic crisis were analyzed.