Publications by authors named "Mario R Reta"
Chagas disease constitutes a major public health problem in Latin America. Human breast milk is a biological sample of great importance for the analysis of therapeutic drugs, as unwanted exposure through breast milk could result in pharmacological effects in the nursing infant. Thus, the goal of breast milk drug analysis is to inquire to which extent a neonate may be exposed to a drug during lactation.
View Article and Find Full Text PDFBackground: Due to migration, Chagas disease is a significant public health problem in Latin America, and in other nonendemic regions. The 2 drugs currently available for the treatment, nifurtimox and benznidazole (BNZ), are associated with a high risk of toxicity in therapeutic doses. Excretion of drug into human breast milk is a potential source of unwanted exposure and pharmacologic effects in the nursing infant.
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- Recent advancements in High-Performance Liquid Chromatography (HPLC) have prioritized faster analysis methods, particularly through improved column technology.
- Short columns packed with sub-2 μm particles are now commonly used with ultra high-pressure instruments, and heating columns above 100°C can help reduce backpressure.
- A study compares the chromatographic performance of conventional particulate columns and a silica-based monolithic column at moderate temperatures, finding the monolithic column to offer enhanced stability and efficiency for fast separations of various pharmaceutical compounds.