Regional climate change scenarios applied to viticultural zoning in Mendoza, Argentina.

Due to the importance of the winemaking sector in Mendoza, Argentina, the assessment of future scenarios for viticulture is of foremost relevance. In this context, it is important to understand how temperature increase and precipitation changes will impact on grapes, because of changes in grapevine phenology and suitability wine-growing regions must be understood as an indicator of climate change. The general objective is to classify the suitable areas of viticulture in Argentina for the current and future climate using the MM5 regional climate change simulations.

Long-term reduction of T-cell intracellular antigens reveals a transcriptome associated with extracellular matrix and cell adhesion components.

Knockdown of T-cell intracellular antigens TIA1 and TIAR contributes to a cellular phenotype characterised by uncontrolled proliferation and tumorigenesis. Massive-scale poly(A+) RNA sequencing of TIA1 or TIAR-knocked down HeLa cells reveals transcriptome signatures comprising genes and functional categories potentially able to modulate several aspects of membrane dynamics associated with extracellular matrix and focal/cell adhesion events. The transcriptomic heterogeneity is the result of differentially expressed genes and RNA isoforms generated by alternative splicing and/or promoter usage.