Publications by authors named "Mario Nicotra"
Exploring the link between pyrethroids exposure and dopaminergic degeneration through morphometric, immunofluorescence, and approaches: the therapeutic role of chitosan-encapsulated curcumin nanoparticles.
Badriyah S Alotaibi Amany Abdel-Rahman Mohamed Yasmina M Abd-Elhakim Ahmed E Noreldin Moustafa Elhamouly Mario Nicotra
Front Pharmacol
May 2024
Article Synopsis
- - The insecticide fenpropathrin (FNE) has been linked to neurotoxic effects similar to those seen in Parkinson's disease, affecting dopaminergic markers and causing oxidative stress in rat models.
- - A study involved 40 male rats divided into four groups to examine the effects of FNE exposure and the protective role of curcumin-encapsulated chitosan nanoparticles (CRM-Chs-NPs) over 60 days.
- - Results showed that FNE led to various harmful changes in the brain, while CRM-Chs-NPs helped reduce toxicity by improving mitochondrial function, enhancing antioxidant activity, and supporting anti-inflammatory responses.
In the current study, matrices of losartan potassium were formulated with two different polymers (Ethocel 10 premium and Ethocel 10FP premium), along with a filler and a lubricant, at different drug-to-polymer / ratios (10:3, 10:4, and 10:5). The matrices were tested by the direct compression method, and their hardness, diameter, thickness, friability, weight variation, content uniformity, and in vitro dissolution tests were assessed to determine 24-h drug release rates. The matrices with Ethocel 10 FP at a 10:4 ratio exhibited pseudo-zero-order kinetics (n-value of 0.
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