Publications by authors named "Mario Meier"
Aims: The utility of clinical risk scores regarding the prediction of major adverse cardiac events (MACE) is uncertain. We aimed to directly compare the prognostic performance of five established clinical risk scores as well as an unstructured integrated clinical judgement (ICJ) of the treating emergency department (ED) physician.
Methods And Results: Thirty-day MACE including all-cause death, life-threatening arrhythmia, cardiogenic shock, acute myocardial infarction (including the index event), and unstable angina requiring urgent coronary revascularization were centrally adjudicated by two independent cardiologists in patients presenting to the ED with acute chest discomfort in an international multicentre study.
We conduct the first 4D-Var inversion of NH accounting for NH bi-directional flux, using CrIS satellite NH observations over Europe in 2016. We find posterior NH emissions peak more in springtime than prior emissions at continental to national scales, and annually they are generally smaller than the prior emissions over central Europe, but larger over most of the rest of Europe. Annual posterior anthropogenic NH emissions for 25 European Union members (EU25) are 25% higher than the prior emissions and very close (<2% difference) to other inventories.
View Article and Find Full Text PDFBackground: We aimed to derive and externally validate a 0/2-h algorithm using the high-sensitivity cardiac troponin I (hs-cTnI)-Access assay.
Methods: We enrolled patients presenting to the emergency department with symptoms suggestive of acute myocardial infarction (AMI) in 2 prospective diagnostic studies using central adjudication. Two independent cardiologists adjudicated the final diagnosis, including all available medical information including cardiac imaging.
Article Synopsis
- The study aimed to validate the effectiveness of the hs-cTnI-VITROS assay for diagnosing acute myocardial infarction (AMI) in emergency department patients.
- It compared the diagnostic performance of hs-cTnI-VITROS to other assays, showing a high accuracy with an AUC of 0.95, indicating it is as reliable as existing assays.
- Using a derived 0/1-h algorithm, the hs-cTnI-VITROS successfully ruled out 53% of patients and maintained a high survival rate of 99.8% at 30 days for those ruled out.
Article Synopsis
- This study aimed to improve the detection of major adverse cardiac events (MACE) in patients suspected of having an acute myocardial infarction (AMI) by combining clinical judgment and ECG findings with a specific troponin testing algorithm.
- Involving over 3,123 patients, it found that the European Society of Cardiology (ESC) hs-cTnT 0/1 h algorithm was more effective at ruling out AMI without increasing the rate of missed MACE cases compared to an extended algorithm.
- While the hs-cTnT algorithm contributed to fewer false positives (rule-in), it outperformed in high predictive values for identifying true positives, indicating it could be a valuable tool in emergency settings for evaluating heart attack risks
Background: The European Society of Cardiology (ESC) recommends the 0/1-h algorithm for rapid triage of patients with suspected non-ST-segment elevation myocardial infarction (MI). However, its impact on patient management and safety when routinely applied is unknown.
Objectives: This study sought to determine these important real-world outcome data.
Background: The aim of this study was to validate the clinical performance of the Beckman Access high-sensitivity cardiac troponin I (hs-cTnI) assay.
Methods: We enrolled patients presenting to the emergency department with symptoms suggestive of acute myocardial infarction (AMI). Final diagnoses were centrally adjudicated by 2 independent cardiologists with all clinical information including cardiac imaging twice: first, using serial hs-cTnT (Elecsys, primary analysis), and second, using hs-cTnI (Architect, secondary analysis) measurements in addition to the clinically used hs-cTn.