Publications by authors named "Mario Kapelle"
Advances in immunotherapy of chronic myeloid leukemia CML.
Stefanie Andrea Erika Held Annkristin Heine Karin Tina Mayer Mario Kapelle Dominik Georg Friedrich Wolf
Curr Cancer Drug Targets
September 2013
Article Synopsis
- Tyrosine kinase inhibitors effectively manage chronic myeloid leukemia (CML) by targeting the BCR-ABL oncogene but do not eliminate CML stem cells, leading to potential relapses.
- Evidence from bone marrow transplants shows the immune system can potentially reject CML stem cells, indicating a path toward a cure.
- Modern immunotherapeutic strategies, such as using autologous dendritic cells and monoclonal antibodies, offer promising avenues for enhancing immune responses and improving treatment outcomes for CML.
Introduction: Intestinal lipase inhibition using tetrahydrolipstatin (Orlistat) has been widely used in the pharmacotherapy of morbid obesity. However, the effects of Orlistat on the secretion of appetite regulating gastrointestinal hormones and appetite sensations are still debated. We addressed whether Orlistat alters the secretion of glucagon-like peptide-1-(7-36)-amide (GLP-1), cholecystokinin (CCK), peptide YY (PYY), and ghrelin as well as postprandial appetite sensations.
View Article and Find Full Text PDF