Does the stop-signal P3 reflect inhibitory control?

The ability to stop already-initiated actions is paramount to adaptive behavior. In psychology and neuroscience alike, action-stopping is a popular model behavior to probe inhibitory control - the underlying cognitive control process that is purportedly vital to regulating thoughts and actions. Starting with seminal work in the 1990s, the frontocentral stop-signal P3 - an event-related potential derived from scalp EEG - has been proposed as a neurophysiological index of inhibitory control during action-stopping.

Common and unique neurophysiological signatures for the stopping and revising of actions reveal the temporal dynamics of inhibitory control.

Inhibitory control is a crucial cognitive-control ability for behavioral flexibility that has been extensively investigated through action-stopping tasks. Multiple neurophysiological features have been proposed to represent 'signatures' of inhibitory control during action-stopping, though the processes signified by these signatures are still controversially discussed. The present study aimed to disentangle these processes by comparing simple stopping situations with those in which additional action revisions were needed.

The human subthalamic nucleus transiently inhibits active attentional processes.

The subthalamic nucleus (STN) of the basal ganglia is key to the inhibitory control of movement. Consequently, it is a primary target for the neurosurgical treatment of movement disorders like Parkinson's disease, where modulating the STN via deep brain stimulation (DBS) can release excess inhibition of thalamocortical motor circuits. However, the STN is also anatomically connected to other thalamocortical circuits, including those underlying cognitive processes like attention.

Hold your horses: Differences in EEG correlates of inhibition in cancelling and stopping an action.

Behavioral adaptation to changing contextual contingencies often requires the rapid inhibition of planned or ongoing actions. Inhibitory control has been mostly studied using the stop-signal paradigm, which conceptualizes action inhibition as the outcome of a race between independent GO and STOP processes. Inhibition is predominantly considered to be independent of action type, yet it is questionable whether this conceptualization can apply to stopping an ongoing action.

Multiple Brain Sources Are Differentially Engaged in the Inhibition of Distinct Action Types.

Most studies contributing to identify the brain network for inhibitory control have investigated the cancelation of prepared-discrete actions, thus focusing on an isolated and short-lived chunk of human behavior. Aborting ongoing-continuous actions is an equally crucial ability but remains little explored. Although discrete and ongoing-continuous rhythmic actions are associated with partially overlapping yet largely distinct brain activations, it is unknown whether the inhibitory network operates similarly in both situations.

Cortical sensorimotor activity in the execution and suppression of discrete and rhythmic movements.

Although the engagement of sensorimotor cortices in movement is well documented, the functional relevance of brain activity patterns remains ambiguous. Especially, the cortical engagement specific to the pre-, within-, and post-movement periods is poorly understood. The present study addressed this issue by examining sensorimotor EEG activity during the performance as well as STOP-signal cued suppression of movements pertaining to two distinct classes, namely, discrete vs.

When two is worse than one: The deleterious impact of multisensory stimulation on response inhibition.

Multisensory facilitation is known to improve the perceptual performances and reaction times of participants in a wide range of tasks, from detection and discrimination to memorization. We asked whether a multimodal signal can similarly improve action inhibition using the stop-signal paradigm. Indeed, consistent with a crossmodal redundant signal effect that relies on multisensory neuronal integration, the threshold for initiating behavioral responses is known for being reached faster with multisensory stimuli.

To start or stop an action depends on which movement we perform: An appraisal of the horse-race model.

In order to gauge the executive processes underlying adaptive behavior, a central criterion in psychology is the extent to which experimental findings generalize across response types. The latency of two major acts of control, action initiation and inhibition, was evaluated using a stop-signal paradigm with two response types, involving either a finger key-pressing or a wrist pen-swiping response. In both conditions, 40 participants were instructed to respond quickly to a GO stimulus but to cancel their responses when a STOP signal was presented, which occurred randomly in 25% of the trials.

Reliability, precision, and clinically important change of the Nine-Hole Peg Test in individuals with multiple sclerosis.

This study evaluated the reliability, precision, and clinically important change of the Nine-Hole Peg Test (9-HPT) over a 1-week period. Sixty-nine patients with multiple sclerosis completed the 9-HPT on two occasions 1 week apart. Test-retest reliability was based on intraclass correlation coefficient, and precision was based on standard error of measurement and coefficient of variation.