A systematic review and meta-analysis assessing adverse event profile and tolerability of nicergoline.

Objective: To evaluate the safety profile of nicergoline compared with placebo and other active agents from published randomised controlled trials.

Design: Systematic review and meta-analysis of nicergoline compared with placebo and other active agents across various indications.

Data Sources: MEDLINE, Medline-in-process, Cochrane, EMBASE, EMBASE alerts, Cochrane Central Register of Controlled Trials (CENTRAL), Cochrane Database of Systematic Reviews (CDSR) and Cochrane Methodology Register (CMR) for all the randomised controlled trials, open-label or blinded, in adults treated with nicergoline.

Cadmium and hypertension in exposed workers: A meta-analysis.

Objectives: In the general population, cadmium seems to be responsible for hypertension, atherosclerosis and an increase in acute coronary events. Therefore, the purpose of this meta-analysis was to analyze controlled studies conducted on cadmium and arterial pressure in occupationally-exposed workers.

Materials And Methods: After analyzing all the relevant articles found in the literature, 6 publications were selected.

Differences between the aging process and the chronic cerebrovascular impairment of memory functioning: the emotional and cognitive interaction.

Three studies illustrate the relationship between memory, emotion, age, and chronic cerebro vascular disorders (CCVDs). In study A, emotion and age interact to produce secondary effects on memory functioning.In study B, emotion-related complaints are correlated with the cognition-related complaints only for high or low lev~ls of impairment For intermediate levels of impairment, the two components of subjective complaints are independent In study C, there is a relationship between aging and the pathological interference by CCVD on memory productivity; young healthy persons do better than aged healthy persons who do better than patients with vascular cognitive impairment (VCI).

Differential characteristics of the aging process and the vascular cognitive impairment in the organization of memory retrieval.

Early identification of cognitive impairment in patients with chronic cerebral vascular disorders can allow for evaluating the time course of the disease up to the phase of conversion to dementia. The specific indicators of pathological cognitive decline should be identifiable vs. the concurrent age-associated changes in memory which accompany the aging process.

Cognitive deficits in schizophrenia: an updated metanalysis of the scientific evidence.

Background: This is an update of a previous meta-analysis published in 2005.

Methods: It includes the data published up to march 2010 for a total of 247 papers and 18,300 cases. Cognitive deficits are examined in 5 different domains: Memory functioning (128 studies), Global cognitive functioning (131 studies), Language (70 studies), Executive function (67 studies), Attention (76 studies).

[Depressive symptoms and personality characteristics: phenomenology of affective disorders].

Aim: Our study aimed to evaluate the relationship between different patterns of symptoms and personality characteristics in a group of 100 patients diagnosed with depression.

Materials And Method: The Minnesota Multiphasic Personality Inventory was used as the personality descriptor by the adoption of a multiaxial interpretative technique (Diamond's Axes). These descriptive variables were correlated with the symptoms referred to by the patients and subsequently underwent factor analysis, the method used for the principal components.

[Assessment of simulation and dissimulation in the MMPI-2 test profiles].

Unlabelled: The aim of this study is to identify the criteria which would allow a differentiation between the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) profiles, obtained from patients who present with problems of minimization of attitude (dissembling) who have shown a minimization of their problems; from patients who answered in a spontaneous and genuine fashion.

Methods: Six hundred and fifty five MMPI profiles of outpatients of the Clinical Psychology Unit, University Hospital, Sapienza University of Rome. Patients were subdivided into two groups, based on the reason for attending: those who submitted voluntarily to a psychodiagnostic assessment and those who were assessed by request of an outside authority, e.

Therapeutic use of nicergoline.

The ergot alkaloid derivative nicergoline became clinically available about 35 years ago in the 1970s. Nicergoline has a broad spectrum of action: (i) as an alpha(1)-adrenoceptor antagonist, it induces vasodilation and increases arterial blood flow; (ii) it enhances cholinergic and catecholaminergic neurotransmitter function; (iii) it inhibits platelet aggregation; (iv) it promotes metabolic activity, resulting in increased utilization of oxygen and glucose; and (v) it has neurotrophic and antioxidant properties. Acting on several basic pathophysiological mechanisms, nicergoline has therapeutic potential in a number of disorders.

Citicoline (Cognizin) in the treatment of cognitive impairment.

Pharmacological treatment of cerebrovascular disorders was introduced at the beginning of the 20th Century. Since then, a multitude of studies have focused on the development of a consensus for a well defined taxonomy of these disorders and on the identification of specific patterns of cognitive deficits associated with them, but with no clear consensus. Nevertheless, citicoline has proved to be a valid treatment in patients with a cerebrovascular pathogenesis for memory disorders.

Relationship between memory, attention, and depression in chronic cerebro-vascular patients.

Vascular dementia patients show a component of their impairment as emotional. In the two studies that we present it was possible to illustrate the characteristics of such emotional component. a.

History of symptomatic therapy in vascular dementia.

The therapy for vascular dementia has known several changes and updates since the use of niacin in the first years of the 20th century. These modifications were due to the parallel evolution of the concept of vascular dementia. Initially, treatments in this area were proposed because they were considered vasoactive and able to increase the blood flow of the brain.