Skin permeation, biocompatibility and antitumor effect of chloroaluminum phthalocyanine associated to oleic acid in lipid nanoparticles.

The objective of this study was to develop and characterize lipid nanoparticles (LNs) containing chloroaluminum phthalocyanine (ClAlPc) to reduce the aggregation of the drug and improve its skin penetration and its antitumor effect. LNs were prepared and characterized by using stearic acid (SA) as solid lipid and oleic acid (OA) as liquid lipid in different proportions. in vitro and in vivo skin penetration was evaluated using modified Franz diffusion cells and fluorescence microscopy, respectively.

Thermally stimulated luminescence and EPR studies on topaz.

In the present work, electron paramagnetic resonance (EPR) spectra and thermoluminescence (TL) emission of colourless natural topaz from Santo Antônio do Jacinto, Brazil, was studied as a function of thermal treatment and gamma irradiation dose, focussing on the use of this material as a radiation dosimeter. EPR measurements on "as-received" samples at room temperature provided signals in the region of about 500 at 5,000 G. The signal located around g approximately equal to 2, frequently attributed to (AlO(4))(0), increased with additional gamma dose and disappeared after thermal treatment at 500 degrees C for 1h.

Evaluation of doses in radiotherapy using solid-state composites based on natural colourless topaz.

The thermoluminescent properties of composites containing powdered topaz embedded in Teflon or glass were studied and compared with the corresponding properties of the well known TLD-100 commercial dosimeters. Relative sensitivity, TL fading, reproducibility of the sample preparation process, and possibility of re-utilisation of the dosimeters were investigated. Measurements of absorbed doses in simulated radiotherapy treatments were also taken.