Harnessing the Reactivity of Duclauxin toward Obtaining PTP1B Inhibitors.

Duclauxin () from sp. IQ-313 was reported as a putative allosteric modulator of human recombinant protein tyrosine phosphatase 1B (400 amino acids) (PTP1B), a validated target for the treatment of type II diabetes. Based on these findings, a one-strain-many-compound (OSMAC) experiment on the IQ-313 strain generated derivatives , , and .