Publications by authors named "Mario Buenrostro-Jauregui"
Article Synopsis
- The study examines how different access protocols to palatable food (PF) influence binge-like eating behaviors in adolescent male Wistar rats, which may be relevant for understanding human obesity.
- Three groups of rats were given varying access to PF—continuous, intermittent, and weekend access—over a period of six weeks, followed by a withdrawal period.
- Results showed that restricted access led to increased binge-like eating, with the intermittent access group exhibiting the highest levels of binge eating, highlighting how food availability affects consumption patterns during adolescence.
The electric stimulation (ES) of the cornea is a novel therapeutic approach to the treatment of degenerative visual diseases. Currently, ES is delivered by placing a mono-element electrode on the surface of the cornea that uniformly stimulates the eye along the electrode site. It has been reported that a certain degree of correlation exists between the location of the stimulated retinal area and the position of the electrode.
View Article and Find Full Text PDFHuman use of marijuana at an early age has been reported to lead to cognitive impairment. However, researchers have not yet clearly determined whether this impairment is due to marijuana-induced alterations in the developing nervous system and whether this deficit persists into adulthood after marijuana use has ceased. We administered anandamide to developing rats to assess the effect of cannabinoids on development.
View Article and Find Full Text PDFPolymorphisms of TNF-alpha (- 308), IL-1beta (+ 3954) and IL1-Ra (VNTR) are associated to severe stage of endometriosis in Mexican women: a case control study.
BMC Womens Health
August 2022
Background: Endometriosis is an estrogen-dependent and chronic inflammatory disease affecting up to 10% of women. It is the result of a combined interaction of genetic, epigenetic, environmental, lifestyle, reproductive and local inflammatory factors. In this study, we investigated whether single nucleotide polymorphisms (SNPs) mapping to TNF-alpha (TNF, rs1800629) and IL-1beta (IL1B, rs1143634) and variable number tandem repeat polymorphism mapping to IL1-Ra (IL1RN intron 2, rs2234663) genetic loci are associated with risk for endometriosis in a Mexican mestizo population.
View Article and Find Full Text PDFArticle Synopsis
- * Recent advancements have led to the discovery of additional neurogenic niches, challenging previous beliefs and sparking debates in the scientific community about their functions and relevance in humans.
- * This review examines existing literature on neurogenic zones, explores molecular mechanisms involved in neurogenesis, and summarizes current knowledge on adult neurogenesis in humans, highlighting similarities and differences across studies.
Article Synopsis
- * Increased cannabis use during adolescence raises concerns about its impact on the ECS and neurogenesis, which is the process of generating new neurons in the brain.
- * The article emphasizes the importance of maintaining a balanced ECS to prevent adverse effects on neural development, which can alter behaviors like stress, anxiety, learning, and memory.
The lateral habenula (LHb) is a phylogenetically primitive brain structure that plays a key role in learning to inhibit distinct responses to specific stimuli. This structure is activated by primary aversive stimuli, cues predicting an imminent aversive event, unexpected reward omissions, and cues associated with the omission of an expected reward. The most widely described physiological effect of LHb activation is acutely suppressing midbrain dopaminergic signaling.
View Article and Find Full Text PDFOne of the most important things in the field of adult hippocampal neurogenesis (AHN) is the identification of the newly generated cells. The immunodetection of thymidine analogs (such as 5-Bromo-2'-deoxyuridine (BrdU)) is a standard technique used for visualizing these newly generated cells. Therefore, BrdU is usually injected in small animals intraperitoneally, so the thymidine analog gets incorporated into dividing cells during DNA synthesis.
View Article and Find Full Text PDFBrainwaves amplitude obtained from electroencephalography (EEG) has been well-recognized as a basis for cognitive capacity, memory, and learning on animals and humans. Adult neurogenesis mechanism is also linked to memory and learning improvement. Traditionally, researchers used to assess learning and memory parameters in rodent models by behavioral tasks.
View Article and Find Full Text PDFThe present article provides a guide for the conduction and analysis of three conditioning-based protocols to evaluate impulsivity in rats. Impulsivity is a meaningful concept because it is associated with psychiatric conditions in humans and with maladaptive behavior in non-human animals. It is believed that impulsivity is composed of separate factors.
View Article and Find Full Text PDFBackground: In behavioral neuroscience studies, it is essential to accurately and easily record rodent sexual behavior. However, current systems are complex, expensive and often require a computer that hinders their use in situ.
New Method: SEXRAT MALE is new software for the real-time annotation and process of live sexual behavior in male rodents.
Article Synopsis
- - The study explored how combining mephedrone (Meph) with ethanol (EtOH) affects neurotransmitter release in the nucleus accumbens (NAc) and medial prefrontal cortex (mPFC) using male rats.
- - Results showed that the combination significantly increased serotonin (5-HT) release, particularly in the NAc, compared to Meph alone; this increase lasted longer in the mPFC.
- - The combination of Meph and EtOH also enhanced locomotor activity, indicating a heightened risk of substance abuse when these drugs are used together, due to their impacts on the brain's reward systems.
Genetic polymorphisms of antioxidant enzymes CAT and SOD affect the outcome of clinical, biochemical, and anthropometric variables in people with obesity under a dietary intervention.
Genes Nutr
January 2018
Article Synopsis
- * Participants were divided into two genetic groups: carriers of mutated genes (CR) and those with normal genes (WT), and significant differences in clinical, biochemical, and anthropometric variables were observed after the intervention.
- * Results indicated that certain genetic polymorphisms led to different responses in health markers like BMI and cholesterol levels, highlighting the role of genetics in individual dietary responses in obesity.
Methylenedioxypyrovalerone (MDPV) is a synthetic cathinone which has recently emerged as a designer drug of abuse. The objective of this study was to investigate the locomotor sensitization induced by MDPV in adolescent mice, and associated neuroplastic changes in the nucleus accumbens and striatum through deltaFosB and CREB expression. Behavioural testing consisted of three phases: Phase I: conditioning regimen with MDPV (0.
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