Publications by authors named "Mario Andrea Latorre"

Introduction: Diverticular disease (DD), commonly associated with the elderly, is becoming more prevalent among younger individuals. This retrospective study aimed to evaluate the differences in the natural history and outcomes between young and old patients with DD.

Methods: Adult patients with DD diagnosed between 2010 and 2022 at an Italian tertiary referral center were enrolled, and their demographic and clinical data were retrieved.

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  • The study investigates the diagnostic delay experienced by pediatric patients with celiac disease across 13 referral centers in Italy, covering cases from 2010 to 2019 and analyzing data in 2023.
  • It finds that the median diagnostic delay for these patients is about 5 months, with a notable portion experiencing extreme delays of 11 months or more.
  • Factors such as age at diagnosis influence delays, with younger patients (under 3 years) generally facing shorter wait times for diagnosis.
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  • The study investigates the diagnostic delays in patients with symptomatic uncomplicated diverticular disease (SUDD) and identifies associated risk factors over a period from 2010 to 2022.
  • A total of 70 patients were analyzed, revealing a median diagnostic delay of 7 months, with 25% initially misdiagnosed with irritable bowel syndrome (IBS).
  • Key findings indicated that past misdiagnosis, high educational levels, and prior abdominal surgeries significantly influenced the extent of diagnostic delays in SUDD cases.
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  • - The study examined diagnostic delays in coeliac disease (CD) among 2362 adult patients across 19 Italian clinics, focusing on overall, patient-related, and physician-related delays.
  • - The median overall diagnostic delay was found to be 8 months, with patient-associated delays averaging 3 months and physician-associated delays averaging 4 months, linked to previous misdiagnosis and neurological symptoms.
  • - The findings highlight the importance of identifying factors that prolong diagnosis, suggesting the need for improved screening strategies for coeliac disease.
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Gastrointestinal (GI) involvement of plasma cell neoplasms is extremely rare. Herein, we describe the case of a 74-year-old Caucasian woman who came to our attention with abdominal pain, food vomiting, and weight loss of 10 kg over 1 year. A computed tomography scan of the abdomen revealed circumferential thickening of terminal ileum, for which the patient underwent an urgent 20-cm-long ileal resection.

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Few conflicting data are currently available on the risk of SARS-CoV-2 infection in patients with autoimmune disorders. The studies performed so far are influenced, in most cases, by the treatment with immunosuppressive drugs, making it difficult to ascertain the burden of autoimmunity per se. For this reason, herein we assessed the susceptibility to COVID-19 in immunosuppressive drug-naïve patients with autoimmune diseases, such as autoimmune gastritis (AIG), celiac disease (CD), type 1 diabetes (T1D), and autoimmune thyroid disease (AITD).

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