Thermoresponsive Zinc TetraPhenylPorphyrin Photosensitizer/Dextran Graft Poly(N-IsoPropylAcrylAmide) Copolymer/Au Nanoparticles Hybrid Nanosystem: Potential for Photodynamic Therapy Applications.

The thermoresponsive Zinc TetraPhenylPorphyrin photosensitizer/Dextran poly (N-isopropylacrylamide) graft copolymer/Au Nanoparticles (ZnTPP/D-g-PNIPAM/AuNPs) triple hybrid nanosystem was synthesized in aqueous solution as a nanodrug for potential use in thermally driven and controlled photodynamic therapy applications. The aqueous solution of the nanosystem has demonstrated excellent stability in terms of aggregation and sedimentation several days after preparation. Optimal concentrations of the components of hybrid nanosystem providing the lowest level of aggregation and the highest plasmonic enhancement of electronic processes in the photosensitizer molecules have been determined.

The role of microplastics biofilm in accumulation of trace metals in aquatic environments.

Microplastics are one of the major contaminants of aquatic nature where they can interact with organic and inorganic pollutants, including trace metals, and adsorb them. At the same time, after the microplastics have entered the aquatic environments, they are quickly covered with a biofilm - microorganisms which are able to produce extracellular polymeric substances (EPS) that can facilitate sorption of trace metals from surrounding water. The microbial community of biofilm contains bacteria which synthesizes EPS with antimicrobial activity making them more competitive than other microbial inhabitants.

Plasmonic enhancement of the antibacterial photodynamic efficiency of a zinc tetraphenylporphyrin photosensitizer/dextran polyacrylamide anionic copolymer/Au nanoparticles hybrid nanosystem.

A zinc tetraphenylporphyrin photosensitizer/dextran polyacrylamide anionic copolymer/Au nanoparticles (ZnTPP/D--PAAan/AuNPs) triple hybrid nanosystem was synthesized in water-based solution as a nanodrug for potential photodynamic therapy applications. Dynamic light scattering studies showed that the nanosystem is stable against aggregation and sedimentation for several days after preparation. The dependence of the ZnTPP fluorescence intensity on the gold concentration in the ZnTPP/D--PAAan/AuNPs nanosystem has been revealed to be non-monotonic, with a maximum 2.

Cerium dioxide nanoparticles increase immunogenicity of the influenza vaccine.

We have demonstrated the influence of cerium dioxide nanoparticles on the immunogenicity of the influenza vaccine on an example of liquid split inactivated Vaxigrip vaccine. Antibody titers were analyzed using the hemagglutination inhibition (HI) assay. Seroprotection, seroconversion, the geometric mean titers (GMTs) and the factor increase (FI) in the GMTs were calculated.

[Use of leukocytic suspension in the treatment of diffuse peritonitis].

Immunocorrection by means of transfusions of donor leukocytes was performed in 64 patients. Transfusions of the leukocytic suspensions in short courses (2-3 transfusions to one patient or 300-500 ml per a course) during the first three days after operation allowed the immune status of organism to be improved and increased the effectiveness of the antibacterial and infusion-detoxication therapy. The greatest medical effect was obtained when using the leukosuspension from donors with natural high (from 1:160 and higher) titers of antibodies to E.