Dye self-organization in doped silica nanoparticles increases the electrochemiluminescence emission in magnetic bead-based assays.

We have investigated the effect of dye distribution on the electrochemiluminescence (ECL) intensity measured with a simplified magnetic bead-based immunoassay for two families of silica nanoparticles (NPs) doped with the cationic Ru(bpy) and the zwitterionic Ru(bpy)bps complexes (bps = bathophenanthroline disulfonate). The NPs doped with the Ru(bpy)bps complex, which can efficiently self-organize in the NP volume favoring ECL generation, resulted in 150-400% signal enhancement compared to the Ru(bpy)-doped ones.

Smartphone-based 3D-printed electrochemiluminescence enzyme biosensor for reagentless glucose quantification in real matrices.

Three-dimensional (3D) printed electrochemical devices are increasingly used in point-of-need and point-of-care testing. They show several advantages such as simple fabrication, low cost, fast response, and excellent selectivity and sensitivity in small sample volumes. However, there are only a few examples of analytical devices combining 3D-printed electrodes with electrochemiluminescence (ECL) detection, an electrochemical detection principle widely employed in clinical chemistry analysis.