Publications by authors named "Marine-Alexia Lefevre"
Article Synopsis
- - The study aims to distinguish between allergic and nonallergic Contact Dermatitis (CD) by analyzing molecular signatures in skin lesions of patients, using patch-testing for diagnosis.
- - Researchers tested 12 allergy biomarkers in lesions from 38 CD patients, finding two patterns: one group showed allergy signatures that correlated with acute allergic reactions, while another group did not.
- - The findings suggest that identifying these molecular signatures could improve patient management by helping to predict those with allergic CD, potentially simplifying treatment approaches.
Background: Tissue-resident memory T (T ) cells are detrimental in allergic contact dermatitis (ACD), in which they contribute to the chronicity and severity of the disease.
Methods: We assessed the impact of a standard topical corticosteroid (TCS) treatment, triamcinolone acetonide (TA), on the formation, maintenance and reactivation of epidermal T cells in a preclinical model of ACD to 2,4-dinitrofluorobenzene. TA 0.
Importance: The pathogenesis of eosinophilic cellulitis (EC) is poorly understood, limiting available treatment options. The current treatment paradigm focuses on delayed type 2 hypersensitivity reaction to various triggers.
Objective: To gain further insight into the nature of EC inflammation and into the cellular signal transduction pathways that are activated in the context of EC.
MiRNAs are non-coding RNA molecules that regulate gene expression at the post-transcriptional level. Although allergic contact dermatitis has been studied extensively, few studies addressed miRNA expression and their role in dendritic cell activation. The main aim of this work was to investigate the role of miRNAs in the underlying mechanism of dendritic cell maturation induced by contact sensitizers of different potency.
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- An aqueous antiseptic containing chlorhexidine digluconate, benzalkonium chloride, and benzyl alcohol (CBB) is commonly used in France, but its potential to cause allergic contact dermatitis (ACD) has been inadequately studied previously.
- A retrospective study analyzed 102 patients with confirmed ACD to CBB, revealing extensive skin lesions in 63% of cases and a significant delay in diagnosis for 55% of patients.
- Positive patch tests for CBB were found in 93.8% of patients, with benzyl alcohol being the main allergen in adults and chlorhexidine digluconate in children, indicating distinct sensitization profiles between age groups.*
Article Synopsis
- The study investigates the reliability of patch tests for diagnosing contact allergy to Amerchol L-101 (AL-101), a potential marker for lanolin allergy.
- A dose-response re-test was performed on 10 subjects, revealing that 8 exhibited positive allergic reactions, often tied to specific gene activity associated with immune response.
- The findings suggest that while AL-101 is an allergen causing both allergy and irritation, molecular profiling could enhance the accuracy of clinical diagnoses.
Background: Skin exposure to chemicals may induce an inflammatory disease known as contact dermatitis (CD). Distinguishing the allergic and irritant forms of CD often proves challenging in the clinic.
Methods: To characterize the molecular signatures of chemical-induced skin inflammation, we conducted a comprehensive transcriptomic analysis on the skin lesions of 47 patients with positive patch tests to reference contact allergens and nonallergenic irritants.
Role of tissue-resident memory T cells in the pathophysiology of allergic contact dermatitis.
Curr Opin Allergy Clin Immunol
August 2021
Purpose Of Review: We bring updated knowledge on tissue-resident memory T cells (TRM), underlining their major role in the recurrence and the severity of allergic contact dermatitis (ACD).
Recent Findings: ACD is a frequently encountered skin disease. It is defined as a delayed-type hypersensitivity reaction initiated by the recruitment of antigen-specific T cells into the skin of sensitized patients.