Ruthenium nitrosyl complexes with NO release capability: the use of fluorene as an antenna.

A ruthenium nitrosyl complex of formula [Ru(fluorene(C6)CHO-terpy)(bipy)(NO)] (AC) in which fluorene(C6) is the 9,9-dihexylfluorene, terpy the 2,2';6',2''-terpyridine, and bipy the 2,2'-bipyridine is presented with its related [Ru(MeO-terpy)(bipy)(NO)] (C) and 9,9-dihexylfluorene 2-hydroxymethylfluorene (A) building blocks. The reference complex C undergoes NO release capabilities under irradiation at = 365 nm. The effect of the introduction of the fluorescent A antenna within the resulting AC complex is discussed both experimentally and theoretically.

Photorelease of Nitric Oxide (NO) in Mono- and Bimetallic Ruthenium Nitrosyl Complexes: A Photokinetic Investigation with a Two-Step Model.

Two monometallic and three bimetallic ruthenium acetonitrile (RuMeCN) complexes are presented and fully characterized. All of them are built from the same skeleton [FTRu(bpy)(MeCN)], in which FT is a fluorenyl-substituted terpyridine ligand and bpy is the 2,2'-bipyridine. The crystal structure of [FTRu(bpy)(MeCN)](PF) is presented.

A Trojan horse approach for enhancing the cellular uptake of a ruthenium nitrosyl complex.

Ruthenium nitrosyl (RuNO) complexes continue to attract significant research interest due to several appealing features that make these photoactivatable nitric oxide (NO˙) donors attractive for applications in photoactivated chemotherapy. Interesting examples of molecular candidates capable of delivering cytotoxic concentrations of NO˙ in aqueous media have been discussed. Nevertheless, the question of whether most of these highly polar and relatively large molecules are efficiently incorporated by cells remains largely unanswered.

Acetylacetonate Ruthenium Nitrosyls: A Gateway to Nitric Oxide Release in Water under Near-Infrared Excitation by Two-Photon Absorption.

A fundamental challenge for phototriggered therapies is to obtain robust molecular frameworks that can withstand biological media. Photoactivatable nitric oxide (NO) releasing molecules (photoNORMs) based on ruthenium nitrosyl (RuNO) complexes are among the most studied systems due to several appealing features that make them attractive for therapeutic applications. Nevertheless, the propensity of the NO ligand to be attacked by nucleophiles frequently manifests as significant instability in water for this class of photoNORMs.

"Click" Chemistry for the Functionalization of Graphene Oxide with Phosphorus Dendrons: Synthesis, Characterization and Preliminary Biological Properties.

Two families of phosphorhydrazone dendrons having either an azide or an alkyne linked to the core and diverse types of pyridine derivatives as terminal functions have been synthesized and characterized. These dendrons were grafted via click reaction to graphene oxide (GO) functionalized with either alkyne or azide functions, respectively. The resulting modified-GO and GO-dendrons materials have been characterized by Fourier Transform Infrared (FTIR), Raman spectroscopy (RS), and Magic Angle Spinning Nuclear Magnetic Resonance (MAS NMR) analyses.

Crystal structure of 1,1'-(pyridine-2,6-di-yl)bis-[-(pyridin-2-ylmeth-yl)methanaminium] dichloride dihydrate.

In the title compound, CHN ·2Cl·2HO, the two pyridine side arms are not coplanar, with the terminal pyridine rings subtending a dihedral angle of 26.45 (6)°. In the crystal, hydrogen bonds, inter-molecular C-H⋯Cl contacts and a weak C-H⋯O inter-action connect the mol-ecule with neighbouring chloride counter-anions and lattice water mol-ecules.

Multistep Photochemical Reactions of Polypyridine-Based Ruthenium Nitrosyl Complexes in Dimethylsulfoxide.

The photorelease of nitric oxide (NO·) has been investigated in dimethylsulfoxide (DMSO) on two compounds of formula [Ru(R-tpy)(bpy)(NO)](PF), in which bpy stands for 2,2'-bipyridine and R-tpy for the 4'--2,2':6',2″-terpyridine with R = H and MeOPh. It is observed that both complexes are extremely sensitive to traces of water, leading to an equilibrium between [Ru(NO)] and [Ru(NO)]. The photoproducts of formula [Ru(R-tpy)(bpy)(DMSO)](PF) are further subjected to a photoreaction leading to a reversible linkage isomerization between the stable Ru-DMSO (sulfur linked) and the metastable Ru-DMSO (oxygen linked) species.

Chemical and photochemical behavior of ruthenium nitrosyl complexes with terpyridine ligands in aqueous media.

The synthesis and behavior in water of a set of various cis(Cl,Cl)-[R-tpyRuCl(NO)](PF) and trans(Cl,Cl)-[R-tpyRuCl(NO)](PF) (R = fluorenyl, phenyl, thiophenyl; tpy = 2,2':6',2''-terpyridine) complexes are presented. In any case, one chlorido ligand is substituted by a hydroxo ligand and the final species arises as a single trans(NO,OH) isomer, whatever the nature of the starting cis/trans(Cl,Cl) complexes. Six X-ray crystal structures are presented for cis(Cl,Cl)-[thiophenyl-tpyRuCl(NO)](PF) (cis-3a), trans(Cl,Cl)-[thiophenyl-tpyRuCl(NO)](PF) (trans-3a), trans(NO,OH)-[phenyl-tpyRu(Cl)(OH)(NO)](PF) (4a), trans(NO,OH)-[thiophenyl-tpyRu(Cl)(OH)(NO)](PF) (4b), trans(NO,OEt)-[phenyl-tpyRu(Cl)(OEt)(NO)](PF) (5a), and trans(NO,OH)-[phenyl-tpyRu(Cl)(OEt)(NO)](PF) (5b) compounds.

Author Correction: Effect of trans(NO, OH)-[RuFT(Cl)(OH)NO](PF) ruthenium nitrosyl complex on methicillin-resistant Staphylococcus epidermidis.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Effect of trans(NO, OH)-[RuFT(Cl)(OH)NO](PF) ruthenium nitrosyl complex on methicillin-resistant Staphylococcus epidermidis.

Antibiotic resistance is becoming a global scourge with 700,000 deaths each year and could cause up to 10 million deaths by 2050. As an example, Staphylococcus epidermidis has emerged as a causative agent of infections often associated with implanted medical devices. S.