Self-assembled nanostructures of L-ascorbic acid alkyl esters support monomeric amphotericin B.

Hypothesis: Amphotericin B (AmB) is a highly effective antimicrobial, with broad antimycotic and antiparasitic effect. However, AmB poor water-solubilisation and aggregation tendency limits its use for topical applications. We studied the capacity of nanostructures formed by alkyl esters of L-ascorbic acid (ASCn) to solubilise AmB and tested the relationship between the prevalence of the monomeric form of AmB and its effectiveness as antimicrobial agent.

Influence of built environment on pedestrian's crossing decision.

The objective of this experimental study is to identify the differentiation made by pedestrians, in their crossing decision, between various urban environments, notably in terms of perception of walking pleasantness and safety. This experiment further aims to identify the environmental features that pedestrians take into account and the inferences they develop and use to explain their road crossing decision. Sets of photographs presenting five different environments (city center, inner suburbs, public housing in the outskirts, commercial zone in the outskirts and countryside) were presented to 77 participants divided up into three age groups (pre-adolescents, young and middle adults).