Publications by authors named "Marine J Chalanqui"
Article Synopsis
- Calcium phosphate-based materials like α-TCP can encourage bone cell differentiation and bone formation but suffer from low bioavailability due to particle size and water affinity.
- A new delivery system using RALA peptide to create α-TCP nanoparticles significantly improves cellular uptake and osteogenic response in osteoblasts.
- Results showed enhanced collagen production and mineralization in both MG-63 cells and porcine mesenchymal stem cells, demonstrating the effectiveness of the RALA/α-TCP nanoparticles in promoting bone tissue development.
Using the layer-by-layer (LbL) assembly technique to deposit mechanically reinforcing coatings onto porous templates is a route for fabricating engineered bone scaffold materials with a combination of high porosity, strength, and stiffness. LbL assembly involves the sequential deposition of nano- to micro-scale multilayer coatings from aqueous solutions. Here, a design of experiments (DOE) approach was used to evaluate LbL assembly of polyethyleneimine (PEI), polyacrylic acid (PAA), and nanoclay coatings onto open-cell polyurethane foam templates.
View Article and Find Full Text PDFMiRNA 34a: a therapeutic target for castration-resistant prostate cancer.
Expert Opin Ther Targets
September 2016
Introduction: Development of a therapy for bone metastases is of paramount importance for castration-resistant prostate cancer (CRPC). The osteomimetic properties of CRPC confer a propensity to metastasize to osseous sites. Micro-ribonucleic acid (miRNA) is non-coding RNA that acts as a post-transcriptional regulator of multiple proteins and associated pathways.
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